When did the Isthmus of Panama form between North and South America?

May 15, 2023
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I think that with the Caribbean plate moving between the Americas more than one isthmus event could have occurred, 20-30Mya, followed by a break up, possibly as the Pebas sea in South America opened and filled in 7-10Mya. This was followed by the present isthmus 3Mya