Its funny everything comes back to Wuhan and Prof. Zhengli who appears to have worked with recombinant Coronavirus derivations involving viral spike proteins for over a decade at Wuhan Institute of Virology, all the way back to 2006 and up to as recently as December, 2019
On December 12, 2019, Prof. Zhengli and her team published the study entitled Molecular mechanism for antibody-dependent enhancement of coronavirus entry on December 11, 2019.
“Coronavirus spike protein mediates viral entry into cells by first binding to a receptor on host cell surface and then fusing viral and host membranes. Our study reveals a novel molecular mechanism for antibody-enhanced viral entry and can guide future vaccination and antiviral strategies. This study reveals complex roles of antibodies in viral entry and can guide future vaccine design and antibody-based drug therapy.”
If you look back at Prof Shi Zhengli's comments from the 2005 onwards she says outright a SARS pandemic will come
1. from bat SARS coronaviruses and it
2. will start in China and that
3. she knows such bat coronaviruses are recombined in the labs to make them gain the ability infect humans.
In a 2008 report Professor Zhengli Shi and others said
“Knowing the capability of different CoVs to recombine ....... in the laboratory [and] gain the ability to infect human cells by acquiring spike protein sequences competent for binding to ACE2 "
Professor Zhengli Shi and her co-authors published a study early last year on March 2, 2019 entitled Bat Coronaviruses in China which said
"Thus, it is highly likely that future SARS- or MERS-like coronavirus outbreaks will originate from bats, and there is an increased probability that this will occur in China."
In just the past five years alone, Prof. Zhengli Shi has almost US$10 million in grants to study coronaviruses from the USA and China.
In 2017 the Guardian reported on Prof Shi finding the source of the 2002 SARS outbreak
"In their study – published in the journal Public Library of Science Pathogens – the Wuhan team reveals that by sequencing the genomes of the different strains of the virus found in horseshoe bats in the cave they found these contained all the genetic pieces that make up the version of Sars virus that caused the 2002 outbreak."
The "outbreak ended in 2004 and the disease has never resurfaced.
But scientists have always feared that Sars could reappear. Hence the efforts of Chinese scientists – led by Shi Zheng-Li and Cui Jie of the Wuhan Institute of Virology, China – to trace the source of the outbreak."
Of SARS it was written in the same article
“There is no effective treatment and no vaccine. It was only contained the last time because it was possible to quarantine people while they were still infectious. Now we have a chance to create vaccines and treatments
"In their paper, the Chinese team warn that another deadly outbreak of Sars could emerge at any time
These were caves in the same area as Prof Shi found in 2013 the virus RaTG13 the closest virus to Covid-19 and also other viruses some of which she had not disclosed.
We are told Prof Shi did no work herself on these new pandemic potential deadly viruses until 2020, they just stayed in a lab fridge, though we know she gene sequenced in part RaTG13 in 2013 and then again fully in 2017/2018. RaTG13 now no longer exists so some have suggested it is possible RaTG13 could have been a recombined lab created viruse using in full or in part samples obtained from the Mojiang Miners who died in 2012 or from other viruses not publically disclosed by Prof Shi. She has confirmed that some viruses she has found have not been disclosed.
Plus this happened at the same Mojiang Mine location where 50% of the miners infected died of an unknown SARS coronavirus in 2012
Professor Zhengli Shi
2008 Prof. Zhengli published the findings of the facts in her report, Difference in Receptor Usage between Severe Acute Respiratory Syndrome (SARS) Coronavirus and SARS-Like Coronavirus of Bat Origin.
which concluded, “Knowing the capability of different CoVs to recombine both in the laboratory and in nature, the possibility that SL-CoVs may gain the ability to infect human cells by acquiring spike protein sequences competent for binding to ACE2 or other surface proteins of human cells can be readily envisaged.”
Professor Zhengli Shi quotes
In 2006, one of China’s preeminent virologists, Professor Zhengli Shi, co-authored the study, Review of Bats and SARS,
concluding that “a SARS epidemic may recur in the future and that SARS-like coronaviruses (SL-CoVs) that originate from different reservoir host populations may lead to epidemics at different times or in different regions…. The recent discovery of a group of diverse SL-CoVs in bats support the possibility of these events….”
Prof. Zhengli and her co-authors published a study early last year on March 2, 2019 entitled Bat Coronaviruses in China
which explicitly warned,
“During the past two decades, three zoonotic coronaviruses have been identified as the cause of large-scale disease outbreaks⁻Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Swine Acute Diarrhea Syndrome (SADS). SARS and MERS emerged in 2003 and 2012, respectively, and caused a worldwide pandemic that claimed thousands of human lives, while SADS struck the swine industry in 2017. They have common characteristics, such as they are all highly pathogenic to humans or livestock, their agents originated from bats, and two of them originated in China. Thus, it is highly likely that future SARS- or MERS-like coronavirus outbreaks will originate from bats, and there is an increased probability that this will occur in China. Therefore, the investigation of bat coronaviruses becomes an urgent issue for the detection of early warning signs, which in turn minimizes the impact of such future outbreaks in China”
Prof Zhengli’s incredibly pertinent report published ten years ago in July, 2010, Identification of key amino acid residues required for horseshoe bat angiotensin-I converting enzyme 2 to function as a receptor for severe acute respiratory syndrome coronavirus
. The study’s abstract can’t be clearer on the immunological risks associated with protein ACE2, with its obvious liability for usurpation by viral agents with a little modified genome sequencing:
“Angiotensin-I converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV). A previous study indicated that ACE2 from a horseshoe bat, the host of a highly related SARS-like coronavirus, could not function as a receptor for SARS-CoV. Here, we demonstrate that a 3 aa change from SHE (aa 40–42) to FYQ was sufficient to convert the bat ACE2 into a fully functional receptor for SARS-CoV. We further demonstrate that an ACE2 molecule from a fruit bat, which contains the FYQ motif, was able to support SARS-CoV infection, indicating a potentially much wider host range for SARS-CoV-related viruses among different bat populations.”
Wuhan Institute of Virology - despite completing the decade-long construction and having the official inauguration of this P4 laboratory on January 31, 2015 — announced by the General Office of Hubei Provincial People’s Government, it wasn’t until 2 and 1/2 years later in January 2018, that the Chinese government announced
that the lab was actually in operation. And ahead of the lab’s second opening in January 2018, biosafety experts and scientists from the United States expressly warned
“that a SARS-like virus could escape,”
One thing we know they worked on is the Origin and evolution of pathogenic coronaviruses
, pioneered by none other than the enormously qualified, highly-decorated, and widely-respected Professor Zhengli Shi, Senior Scientist and Principal Investigator.
In 2014, Prof. Zhengli began to win particularly large sums of grant funding for the express purpose of researching and experimenting with coronaviruses — often receiving numerous, overlapping grants for the same time period. What’s just as interesting is where a lot of this funding originated — the US government. On January 6, 2014, Prof. Zhengli received a US$665,000 grant from the National Institute of Health for a study named The Ecology of Bat Coronaviruses and the Risk of Future Coronavirus Emergence
(NIAID R01 AI1 10964) and then four days later on January 10, 2014, an additional US$559,500 grant from the United States Agency of International Development for research studied entitled Emerging Pandemic Threats PREDICT 2_China
(Project No. AID-OAA-A-14–00102).
She concurrently received similarly significant grants from the National Basic Research program of China, the Chinese Academy of Science, the National Natural Science Foundation of China, and from the Strategic Priority Research Program of Chinese Academy of Sciences totaling over US$2,500,000 for researching interspecies transmission of zoonotic viruses, the identification, genetic evolution and pathogenesis of bat viruses, the genetic variation of pathogens in Africa, the evolution mechanism of the adaptation of bat SARS-related coronaviruses to host receptor molecules, the risk of interspecies infection, genetic evolution and transmission mechanism of important bat-borne viruses, and pathogen biology studies on novel swine coronaviruses.
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