This may be of interest .This need for non-locality is necessary to instantiate individuality not just on Earth while it exists and is viable, but also within the systems and galaxies of this vast Higgs constrained universe, and throughout nature.
This may be of interest .
I always try to look at things from a most basic perspective. There is no irreducible complexity, therefore all research must start at its most fundamental origin, or be traced back to its fundamental origins.At first the comprehension that ones’ first person individuality is abstracted, separate, and distinct from the evolution, development, and life of ones’ cells is a tough hurdle for the mind to overcome. Even as it is viewed from various perspectives, and in the absence of clarifying empirical evidence, it requires some time alone in contemplation and a steely objectivity to come to realize the truth of it. However humankind has had this problem before. (POST #15)
Although biology has always been a science of complex systems, complexity itself has only recently acquired the status of a new concept, partly because of the advent of electronic computing and the possibility of simulating complex systems and biological networks using mathematical models (Emmeche, 1997; Alm & Arkin, 2003).
Because complex systems have emergent properties, it should be clear from the preceding discussion that their behaviour cannot be understood or predicted simply by analysing the structure of their components. The constituents of a complex system interact in many ways, including negative feedback and feed-forward control, which lead to dynamic features that cannot be predicted satisfactorily by linear mathematical models that disregard cooperativity and non-additive effects. In view of the complexity of informational pathways and networks, new types of mathematics are required for modelling these systems (Aderem & Smith, 2004).
Galaxies do not evolve from dust;
The LINE hypothesis proposes that UTE’s instantiate galaxoids that typically evolve into galaxies. This places a minimum limit on the initial state (mass, size, gravitation, etc.) of galaxy formation to that of a typical galaxoid. Below this minimum only the central primordial black hole exists, having any possible size. Such primordial black holes that do not form a galaxoid could still rarely, circumstantially seed a new galaxy. After each UTE, galaxoids circumstantially emerge with different accumulations of information as its’ encompassing WOF halo. WOF halos having different masses and densities encompassing a central black hole forms galaxoids that begin their long evolution into galaxies. Hence, because galaxies don’t evolve from dust, galaxies will be observed to have larger than expected initial masses and sizes and will appear more evolved at the earliest observable stages of universal expansion.
Pyrin, encoded by the MEFV gene, is best known for its gain-of-function mutations causing familial Mediterranean fever (FMF), an autoinflammatory disease. Pyrin forms a caspase-1-activating inflammasome in response to inactivating modifications of Rho GTPases by various bacterial toxins or effectors.
Pyrin-mediated innate immunity is unique in that it senses bacterial virulence rather than microbial molecules, but its mechanism of activation is unknown. Here we show that Pyrin was phosphorylated in bone marrow-derived macrophages and dendritic cells.
In context of the OP question, your missive on pyrine and my search of what pyrine is in the scheme of things
Robert Hazen posits that the current dichotomy between "life is abundant" or "life is extremely rare" is the wrong way of looking at the question.It's worth noting that these assumptions and speculations are not currently proven or disproven by scientific research and it's an open-ended discussion that could lead to many different perspectives and interpretations.