No!, no one should be injected or have the Coronavirus contagion deliberately to test a vaccine.
This is what Albert Neisser did in 19th century Prussia with his syphilis vaccine, no syphilis vaccine ever worked; when some victims of experiment actually had syphilis, Neisser said it was because of their high risk behavior. This prompted the Prussian kingdom to issue the first rules ever about experiments in humans. The infamous Tuskegee and Central America experiments were a worse remake of Neisser crimes.
The V-19 spreads fast, is an easy contagion, thus a cohort, observational study may perhaps go, HRA will say if a RND, placebo controlled trial is needed. This morality doubt arouse long time after Zidovudine was tested in Africa to block vertical transmission of HIV, newborn get it when going through delivery channel, this is the same rationale as in PrEP (Why the decades gap between Zidovudine for women about to delivery, and PrEP?), some claim about dubious morality of a RND, Placebo controlled trial, when an observational study may have been enough.
For sure, double blind, placebo controlled studies provide the best evidence of activity for a registration, no way to accept a deliberate contagion of a potentially deadly virus to test efficacy of a vaccine, chances of contagion in an usual way of living can be assessed, and from this figures, the size of sample to be followed defined, the recent case of Dengue vaccine problems can be considered, but this differs in that is the second Dengue infection, or a first wild virus infection in a vaccinated subject what is more harmful, also the strains that produce the worse, more deadly second Dengue infection are those circulating in Asia, American Dengue strains are milder. Blessings +