SARS-CoV-2 may be exploiting our immune system's 'first responder' cells

[admin]

It's possible that an immune response may be helping the virus invade certain cells.

SARS-CoV-2 may be exploiting our immune system's 'first responder' cells : Read more

 

[VennieThompson]

These statements appear to contradict the findings described in "How ACE2 Reduction Effects COVID-19 Severity", an article in HCP Live describing the observation of an NIH NIA set of findings by clinicians out of Maryland that despite the virus targeting cells through ACE2, the reduced levels of ACE2 associated with aging places those with lower ACE2 levels at greater risk for poor COVID-19 outcomes. Younger persons with greater ACE2 expression have less severe disease. It would appear from deeper investigation of the available EVIDENCE that increased ACE2 output response is advantageous regardless of ACE2 being a cellular access point for the virus.

 

[mhiriart]

Dear Vennie, ACE2 is more abundant in older people.

It would be interesting to know which kind of interferon is responsible to increase the receptor.

 

[VennieThompson]

You really need to survey the available literature. "The Scientist"ossible Biological Explanations for Kids Escape from COVID-19". Every bit of literature on ACE2 assessment surveys and studies shows lower ACE2 in the elderly and those with type 2 diabetes and pulmonary hypertension. This is referred to as a "paradoxical" finding. The important difference between the elderly and children in immune response isn't high non-existent high incidence of ACE2 in the vulnerable elderly, but low NK T-cell levels in the elderly as opposed to children's high levels of these T2 cells.

I recommend that LiveScience staff research their articles better. This naked assertion on your part against the evidence in the literature is the sort of thing which should be removed by a moderator as dangerous.

 

[VISWANATHA SARMA DONEPUDI]

TRUE AS SAID BY VENNIE WHAT IS IMPORTANT IS THE NK T-CELL LEVELS RATHER THAN ITHE ACE-2 LEVELS. THE EVIDENCE IN LITERATURE AVAILABLE IS IN SUPPORT OF WHAT VENNIE SAID..IT IS TRUE THAT SUCH CRUCIAL INFORMATION IS DOUBLE CHECKED BEFORE REACHING THE WORLD IN PRINT.

 

[VennieThompson]

Thank You kind Sir!

 

[Wjstang65]

Has anyone seen the literature on ACE2 and Vit D3 uptake. This would explain the high risk groups: elderly, obese, cardiovascular, diabetes and greater melanin levels that inhibits Vit D processing in higher latitudes?