The key determinants of the morbidity and mortality with COVID 19 seems to me, seems to be existence of:
1- Artherosclerosis (hypertension, ageing ...)
- Kids don't have artherosclerosis, thus they rarely suffer of any complications of COVID 19.
- The older you are, the greater the risk of atherosclerosis, the greater the risk of dying of COVID
- Prevalence of artherosclerosis is higher in men than women- more men die of COVID 19 than women
2- Hypercoagulability
Controversial and difficult to accept but COVID seems to be binding to RBCs and leading to thrombosis both venous and arterial...
COVID is a disease like no other one. This means that it pathophysiology does not fit with traditional knowledge. We need to think outside the box and accept concept that may sound "ridiculous"- COVID may well be binding to RBCs
I might be wise to start anticoagulation as soon as the diagnosis of Covid 19 is made. We are probably seeing or admitting patients too late when venous and arterial thrombosis is already present and undiagnosed.
I wonder if patients at high of arteriosclerosis with the diagnosis COVID 19 were all started on anticoagulation as soon as the diagnosis was made, the burden of the disease would be so big.