Question Effective COVID-19 Vaccines?! But will Anti-Vaxxers prevent elimination of the pandemic?!

[PseudaFed]

You might find this interesting; from a brief scan of the paper, apparantly this kind of technology presents minimal risk of both ADE and virus evasion through mutation:

A vaccine that mimics the coronavirus prompts potent antibodies

A COVID-19 vaccine candidate made of tiny artificial particles could be more powerful than other leading varieties at triggering a protective immune response.

David Veesler and Neil King at the University of Washington in Seattle and their colleagues designed microscopic ball-shaped particles that mimic the structure of a virus (A. C. Walls et al. Cell https://doi.org/fg6r; 2020). The researchers fused 60 copies of SARS-CoV-2’s spike protein — the part of the virus that allows it to infect human cells — to the outside of each of these ‘nanoparticles’.

When the team injected mice with the nanoparticle vaccine, the animals produced virus-blocking antibodies at levels comparable to or greater than those produced by people who had recovered from COVID-19. Mice that received the vaccine produced about ten times more of these antibodies than did rodents vaccinated only with the spike protein, on which many COVID-19 vaccine candidates rely.

The vaccine also appears to produce a strong response from special immune cells that help to mount a fast defence after infection with SARS-CoV-2.

 

[Chem721]

Mice that received the vaccine produced about ten times more of these antibodies than did rodents vaccinated only with the spike protein, on which many COVID-19 vaccine candidates rely.

Very interesting post. thank you!

For cellular activity to initiate the production of neutralizing antibodies, the antigen(s) must be "presented" to antibody producing cells in a manner that optimizes antibody production and neutralization. There is a complex interplay between cellular and immunochemical components required for a robust response, assuming you have a viable immune system.

Adjuvants are used in vaccines for this very reason. They were definitely shown to enhance the effectiveness of many vaccines, a vital consideration. The higher the active immunity rate following vaccination, the more likely the virus will be wiped out. It is good to see they are developing molecularly "non-invasive" vaccine candidates!!, unlike those of RNA and DNA. And with considerable experience in immunochemistry myself. it comes as no surprise that a unique "delivery" system like the one described is demonstrating an equal or higher apparent immunity. It is a phony virus particle, but with only the spike protein. Sounds great.

Will have to follow this up.