Diabetes drug led to dramatic weight loss in large trial

Mar 20, 2021
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Jul 2, 2020
It would be really interesting to independently test these drugs against the use of gut bacteria treatments to see the long term and probably cheaper benefits of using gut bacteria.

Gut Bacteria studies have shown amazing health effects on a range of human health conditions, including a greater nutritional benefit from a lower calorie diet in studies on children compared to a 20% higher calorie diet

In fact, it's estimated that the human gut contains 100 trillion bacteria, or 10 times as many bacteria as cells in the human body.

These bacteria, or gut flora, influence health in many ways, from helping to extract energy from food to building the body's immune system, to protecting against infection with harmful, disease-causing bacteria.

Researchers are only just beginning to understand how differences in the composition of gut bacteria may influence human health. From what we know so far, here are five ways gut flora affect wellness:


A growing body of research suggests that gut bacteria influence weight. One recent study found that obese people have a less diversity in their gut flora than lean people. Other studies have suggested that an increase in a group of gut bacteria called Firmicutes, and a decrease in a group of gut bacteria called Bacteroidetes, are linked with obesity.

Research done on animals may provide clues about how gut bacteria affect weight gain. One recent study found that mice that received a "gut bacteria transplant" from an obese person gained more weight and fat mass than those who received bacteria from a lean person.

What's more, the transplant altered the metabolism of the mice: animals that received gut bacteria from an obese person had metabolic changes linked with obesity in humans (such as increased production of compounds called branched-chain amino acids); while those that received gut bacteria from a lean person had metabolic changes linked with reduced body weight (such as increased breakdown of carbohydrates).

Limitations of the use of drugs include cost and life time use... without independent research on alternatives or incentives to allow drug makers to profit from the research showing how bacteria and natural alternatives can be beneficial we are unlikely to be provided with balanced information

Quote from this livescience post on .... the diabetes drug Semaglutide

The study on the drug Semaglutide did not look at the drug's effects beyond 68 weeks, and people would likely need to stay on the drug for life to prevent their weight from coming back, the Times reported.

And weight loss drugs that appear to do well in trials may not be as effective in real-world settings, according to CNN. What's more, several weight loss drugs that achieved approval from the Food and Drug Administration were later recalled because of side effects, CNN reported.

The study was funded by the maker of semaglutide, Novo Nordisk. The Danish pharmaceutical company has already submitted an application with the FDA for approval of semaglutide for chronic weight management, according to CNN.

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